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Preneoplastic lesion growth driven by the death of adjacent normal stem cells

Clonal expansion of premalignant lesions is an important step in the progression to cancer. This process is commonly considered to be a consequence of sustaining a proliferative mutation. Here, we investigate whether the growth trajectory of clones can be better described by a model in which clone g...

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Detalhes bibliográficos
Main Authors: Chao, Dennis L., Eck, J. Thomas, Brash, Douglas E., Maley, Carlo C., Luebeck, E. Georg
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567488/
https://ncbi.nlm.nih.gov/pubmed/18815380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802211105
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