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Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes
Rab GTPases and ubiquitination are critical regulators of transmembrane cargo sorting in endocytic and lysosomal targeting pathways. The endosomal protein Rabex-5 intersects these two layers of regulation by being both a guanine nucleotide exchange factor (GEF) for Rab5 and a substrate for ubiquitin...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2008
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2567407/ https://ncbi.nlm.nih.gov/pubmed/18772883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.177 |
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