Pnc1p-Mediated Nicotinamide Clearance Modifies the Epigenetic Properties of rDNA Silencing in Saccharomyces cerevisiae

The histone deacetylase activity of Sir2p is dependent on NAD(+) and inhibited by nicotinamide (NAM). As a result, Sir2p-regulated processes in Saccharomyces cerevisiae such as silencing and replicative aging are susceptible to alterations in cellular NAD(+) and NAM levels. We have determined that h...

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Bibliografiska uppgifter
Huvudupphovsmän: McClure, Julie M., Gallo, Christopher M., Smith, Daniel L., Matecic, Mirela, Hontz, Robert D., Buck, Stephen W., Racette, Frances G., Smith, Jeffrey S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Genetics Society of America 2008
Ämnen:
Investigations
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567381/
https://ncbi.nlm.nih.gov/pubmed/18780747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.091090
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