Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production

Regulation of IL-6 transsignaling by the administration of soluble gp130 (sgp130) receptor to capture the IL-6/soluble IL-6R complex has shown promise for the treatment of rheumatoid arthritis (RA). However, enhancing endogenous sgp130 via alternative splicing of the gp130 gene has not yet been test...

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Detalhes bibliográficos
Main Authors: Ahmed, Salahuddin, Marotte, Hubert, Kwan, Kevin, Ruth, Jeffrey H., Campbell, Phillip L., Rabquer, Bradley J., Pakozdi, Angela, Koch, Alisa E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567200/
https://ncbi.nlm.nih.gov/pubmed/18796608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802675105
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