Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element

Nuclear export of certain HIV-1 mRNAs requires an interaction between the viral Rev protein and the Rev response element (RRE), a structured element located in the Env region of its RNA genome. This interaction is an attractive target for both drug design and gene therapy, exemplified by RevM10, a t...

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Bibliographische Detailangaben
Hauptverfasser: Legiewicz, Michal, Badorrek, Christopher S., Turner, Kevin B., Fabris, Daniele, Hamm, Tiffany E., Rekosh, David, Hammarskjöld, Marie-Louise, Le Grice, Stuart F. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567145/
https://ncbi.nlm.nih.gov/pubmed/18776047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804461105
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