Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.

The biochemical properties of four acyclovir-resistant mutants are described. Two of these mutants, PAAr5 and BWr, specified nucleotidyl transferase (DNA polymerase) activities which were less sensitive to inhibition by acyclovir triphosphate than their wild-type counterparts. Another mutant, IUdRr,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Furman, P A, Coen, D M, St Clair, M H, Schaffer, P A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1981
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC256706/
https://ncbi.nlm.nih.gov/pubmed/6275127
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