Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.

The biochemical properties of four acyclovir-resistant mutants are described. Two of these mutants, PAAr5 and BWr, specified nucleotidyl transferase (DNA polymerase) activities which were less sensitive to inhibition by acyclovir triphosphate than their wild-type counterparts. Another mutant, IUdRr,...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Furman, P A, Coen, D M, St Clair, M H, Schaffer, P A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC256706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6275127/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.40.3.936-941.1981
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