Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.

The biochemical properties of four acyclovir-resistant mutants are described. Two of these mutants, PAAr5 and BWr, specified nucleotidyl transferase (DNA polymerase) activities which were less sensitive to inhibition by acyclovir triphosphate than their wild-type counterparts. Another mutant, IUdRr,...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Furman, P A, Coen, D M, St Clair, M H, Schaffer, P A
Médium: Artigo
Jazyk:Inglês
Vydáno: 1981
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC256706/
https://ncbi.nlm.nih.gov/pubmed/6275127
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky