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Characterization of the spontaneous “aging” of the heme oxygenase from the pathological bacterium Neisseria meningitidis via cleavage of the C-terminus in contact with the substrate; Implications for functional studies and the crystal structure

Solution (1)H NMR spectroscopy and mass spectrometry are utilized to characterize the irreversible “aging” of native heme oxygenase from N. meningitidis, NmHO. 2D NMR characterization of the cyanide-inhibited substrate complex shows that the C-terminal interaction between Arg208His209 and the expose...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Liu, Yangzhong, Ma, Li-Hua, Zhang, Xuhong, Yoshida, Tadashi, Satterlee, James D., La Mar, Gerd N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566967/
https://ncbi.nlm.nih.gov/pubmed/16548515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0523097
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