Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region

The interplay between dopamine and α-synuclein (AS) plays a central role in Parkinson's disease (PD). PD results primarily from a severe and selective devastation of dopaminergic neurons in substantia nigra pars compacta. The neuropathological hallmark of the disease is the presence of intraneu...

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Autors principals: Herrera, Fernando E., Chesi, Alessandra, Paleologou, Katerina E., Schmid, Adrian, Munoz, Adriana, Vendruscolo, Michele, Gustincich, Stefano, Lashuel, Hilal A., Carloni, Paolo
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566601/
https://ncbi.nlm.nih.gov/pubmed/18852892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003394
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