Transactivation of Cellular Genes Involved in Nucleotide Metabolism by the Regulatory IE1 Protein of Murine Cytomegalovirus Is Not Critical for Viral Replicative Fitness in Quiescent Cells and Host Tissues

Despite its high coding capacity, murine CMV (mCMV) does not encode functional enzymes for nucleotide biosynthesis. It thus depends on cellular enzymes, such as ribonucleotide reductase (RNR) and thymidylate synthase (TS), to be supplied with deoxynucleoside triphosphates (dNTPs) for its DNA replica...

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Main Authors: Wilhelmi, Vanessa, Simon, Christian O., Podlech, Jürgen, Böhm, Verena, Däubner, Torsten, Emde, Simone, Strand, Dennis, Renzaho, Angélique, Lemmermann, Niels A. W., Seckert, Christof K., Reddehase, Matthias J., Grzimek, Natascha K. A.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
主題:
Genome Replication and Regulation of Viral Gene Expression
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566287/
https://ncbi.nlm.nih.gov/pubmed/18684825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00928-08
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