Hyperproliferation of B Cells Specific for a Weakly Immunogenic PorA in a Meningococcal Vaccine Model

Highly homologous meningococcal porin A (PorA) proteins induce protective humoral immunity against Neisseria meningitidis group B infection but with large and consistent differences in the levels of serum bactericidal activity achieved. We investigated whether a poor PorA-specific serological outcom...

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Main Authors: Luijkx, Thomas A., van Gaans-van den Brink, Jacqueline A. M., van Dijken, Harry H., van den Dobbelsteen, Germie P. J. M., van Els, Cécile A. C. M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Vaccine Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565936/
https://ncbi.nlm.nih.gov/pubmed/18768670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00192-08
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