A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity

BACKGROUND: Group B Neisseria meningitidis, an endotoxin-producing Gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated in Europe from 8 weeks of age. Endotoxin components of outer membrane vesicles...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Dowling, David J., Sanders, Holly, Cheng, Wing Ki, Joshi, Sweta, Brightman, Spencer, Bergelson, Ilana, Pietrasanta, Carlo, van Haren, Simon D., van Amsterdam, Sandra, Fernandez, Jeffrey, van den Dobbelsteen, Germie P. J. M., Levy, Ofer
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143884/
https://ncbi.nlm.nih.gov/pubmed/28008331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00562
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