Development of Caspofungin Resistance following Prolonged Therapy for Invasive Candidiasis Secondary to Candida glabrata Infection

We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution w...

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Autori principali: Thompson, George R., Wiederhold, Nathan P., Vallor, Ana C., Villareal, Nyria C., Lewis, James S., Patterson, Thomas F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Mechanisms of Resistance
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565919/
https://ncbi.nlm.nih.gov/pubmed/18676885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00473-08
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