Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin producti...

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Hlavní autoři: Cota, Jason M., Grabinski, Jodi L., Talbert, Robert L., Burgess, David S., Rogers, P. David, Edlind, Thomas D., Wiederhold, Nathan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258485/
https://ncbi.nlm.nih.gov/pubmed/18086838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01542-07
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