Increases in SLT2 Expression and Chitin Content Are Associated with Incomplete Killing of Candida glabrata by Caspofungin

Incomplete killing was observed for caspofungin against Candida glabrata, which was associated with increased SLT2 expression and elevated chitin content. In contrast, fungicidal activity and no chitin increase were observed in an isogenic Δslt2 strain, suggesting a role for SLT2 and chitin producti...

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Main Authors: Cota, Jason M., Grabinski, Jodi L., Talbert, Robert L., Burgess, David S., Rogers, P. David, Edlind, Thomas D., Wiederhold, Nathan P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Resistance
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258485/
https://ncbi.nlm.nih.gov/pubmed/18086838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01542-07
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