Molecular and Biochemical Characterization of SHV-56, a Novel Inhibitor-Resistant β-Lactamase from Klebsiella pneumoniae

A clinical strain of Klebsiella pneumoniae was found to possess the chromosomal gene bla(SHV-56), encoding a new inhibitor-resistant β-lactamase with a pI of 7.6. SHV-56 is derived from SHV-11 by the single substitution K234R. This mutation therefore evidences a new critical site for inhibitor resis...

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Autores principales: Dubois, Véronique, Poirel, Laurent, Demarthe, François, Arpin, Corinne, Coulange, Laure, Minarini, Luciene A. R., Bezian, Marie-Christine, Nordmann, Patrice, Quentin, Claudine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565901/
https://ncbi.nlm.nih.gov/pubmed/18663019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00387-08
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