Emergence in Klebsiella pneumoniae of a Chromosome-Encoded SHV β-Lactamase That Compromises the Efficacy of Imipenem

A Klebsiella pneumoniae isolate was identified that had reduced susceptibility to several expanded-spectrum cephalosporins and imipenem. That isolate produced a chromosome-encoded SHV-type β-lactamase, SHV-38, that had an alanine to valine substitution in position Ambler 146 compared to β-lactamase...

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Bibliografiske detaljer
Main Authors: Poirel, Laurent, Héritier, Claire, Podglajen, Isabelle, Sougakoff, Wladimir, Gutmann, Laurent, Nordmann, Patrice
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC151740/
https://ncbi.nlm.nih.gov/pubmed/12543688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.2.755-758.2003
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