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Staudinger Ligation of Peptides at Non-Glycyl Residues

The Staudinger ligation provides a means to form an amide bond between a phosphinothioester and azide. This reaction holds promise for the ligation of peptides en route to the total chemical synthesis of proteins. (Diphenylphosphino)methanethiol is the most efficacious of known reagents for mediatin...

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Autors principals: Soellner, Matthew B., Tam, Annie, Raines, Ronald T.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565276/
https://ncbi.nlm.nih.gov/pubmed/17168602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo0620056
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