Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (TPH1 and TPH2). We used a gene-targeting approach to generate mice with selectiv...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Savelieva, Katerina V., Zhao, Shulei, Pogorelov, Vladimir M., Rajan, Indrani, Yang, Qi, Cullinan, Emily, Lanthorn, Thomas H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2008
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565062/
https://ncbi.nlm.nih.gov/pubmed/18923670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003301
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