Models from experiments: combinatorial drug perturbations of cancer cells

We present a novel method for deriving network models from molecular profiles of perturbed cellular systems. The network models aim to predict quantitative outcomes of combinatorial perturbations, such as drug pair treatments or multiple genetic alterations. Mathematically, we represent the system b...

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Detalhes bibliográficos
Main Authors: Nelander, Sven, Wang, Weiqing, Nilsson, Björn, She, Qing-Bai, Pratilas, Christine, Rosen, Neal, Gennemark, Peter, Sander, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564730/
https://ncbi.nlm.nih.gov/pubmed/18766176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2008.53
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