Mechanisms of G2 Arrest in Response to Overexpression of p53

Overexpression of p53 causes G2 arrest, attributable in part to the loss of CDC2 activity. Transcription of cdc2 and cyclin B1, determined using reporter constructs driven by the two promoters, was suppressed in response to the induction of p53. Suppression requires the regions −287 to −123 of the c...

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Veröffentlicht in:	Mol Biol Cell
Hauptverfasser:	Taylor, William R., DePrimo, Samuel E., Agarwal, Archana, Agarwal, Munna L., Schönthal, Axel H., Katula, Karen S., Stark, George R.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Cell Biology 1999
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25646/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10564259/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.10.11.3607
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