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CHEK2 I157T associates with familial and sporadic colorectal cancer

BACKGROUND: Recently, a functionally defective CHEK2 variant I157T has been proposed to associate with an increased risk of several types of cancer. We investigated the CHEK2 I157T variant for colorectal cancer (CRC) predisposition in a large population based study including a significant number of...

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Detalhes bibliográficos
Main Authors: Kilpivaara, O, Alhopuro, P, Vahteristo, P, Aaltonen, L A, Nevanlinna, H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564563/
https://ncbi.nlm.nih.gov/pubmed/16816021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.038331
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