The MYCN oncogene is a direct target of miR-34a

Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an aggressive phenotype. Database searches identified 5 microRNAs that map to the commonly deleted region of 1p36 and we hypothesized that the loss of one or more of these microR...

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Autori principali: Wei, Jun Stephen, Song, Young Kook, Durinck, Steffen, Chen, Qing-Rong, Cheuk, Adam Tai Chi, Tsang, Patricia, Zhang, Quangeng, Thiele, Carol Jean, Slack, Andrew, Shohet, Jason, Khan, Javed
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562938/
https://ncbi.nlm.nih.gov/pubmed/18504438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.154
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