A Cocaine Hydrolase Engineered from Human Butyrylcholinesterase Selectively Blocks Cocaine Toxicity and Reinstatement of Drug Seeking in Rats

Successive rational mutations of human butyrylcholinesterase (BChE) followed by fusion to human serum albumin have yielded an efficient hydrolase that offers realistic options for therapy of cocaine overdose and abuse. This albumin-BChE prevented seizures in rats given a normally lethal cocaine inje...

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Bibliografiske detaljer
Main Authors: Brimijoin, Stephen, Gao, Yang, Anker, Justin J, Gliddon, Luke A, LaFleur, David, Shah, R, Zhao, Qinghai, Singh, M, Carroll, Marilyn E
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562914/
https://ncbi.nlm.nih.gov/pubmed/18199998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.npp.1301666
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