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The Mismatch Repair-Mediated Cell Cycle Checkpoint Response to Fluorodeoxyuridine
The loss of DNA mismatch repair (MMR) is responsible for hereditary nonpolyposis colorectal cancer and a subset of sporadic tumors. Acquired resistance or tolerance to some anti-cancer drugs occurs when MMR function is impaired. 5-Fluorouracil (FU), an anti-cancer drug used in the treatment of advan...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562697/ https://ncbi.nlm.nih.gov/pubmed/18543256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21824 |
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