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Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology

The development of recombinant adeno-associated virus (rAAV) gene therapy applications is hampered by the inability to produce rAAV in sufficient quantities to support pre-clinical and clinical trials. Contrasting with adherent cell cultures, suspension cultures provide a straightforward means for e...

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Detalhes bibliográficos
Main Authors: Negrete, Alejandro, Kotin, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562640/
https://ncbi.nlm.nih.gov/pubmed/18632744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bfgp/eln034
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