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Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene

The cancer chemotherapeutic agent mitomycin C (MC) alkylates and cross-links DNA monofunctionally and bifunctionally in vivo and in vitro, forming six major MC-deoxyguanosine adducts of known structures. The synthesis of one of the monoadducts (8) by the postoligomerization method was accomplished b...

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Detalhes bibliográficos
Main Authors: Champeil, Elise, Paz, Manuel M., Ladwa, Sweta, Clement, Cristina C., Zatorski, Andrzej, Tomasz, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562617/
https://ncbi.nlm.nih.gov/pubmed/18588303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802118p
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