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Origins of Enhanced Proton Transport in the Y7F Mutant of Human Carbonic Anhydrase II
Human carbonic anhydrase II (HCA II), among the fastest enzymes known, catalyzes the reversible hydration of CO(2) to [Formula: see text]. The rate-limiting step of this reaction is believed to be the formation of an intramolecular water wire and transfer of a proton across the active site cavity fr...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562593/ https://ncbi.nlm.nih.gov/pubmed/18671353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802264j |
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