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Epigenetic regulation of chromatin structure and gene function by biotin: are biotin requirements being met?
Histones H2A, H3, and H4 are modified by covalent binding of the vitamin biotin to distinct lysine residues. Binding of biotin to histones is mediated by holocarboxylase synthetase (HCS) and perhaps biotinidase. Biotinylation of lysine- 12 in histone H4 (K12BioH4) plays roles in gene repression, sta...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562292/ https://ncbi.nlm.nih.gov/pubmed/18673490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1753-4887.2008.00073.x |
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