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Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling

We have identified two genes, Smed-PTEN-1 and Smed-PTEN-2, capable of regulating stem cell function in the planarian Schmidtea mediterranea. Both genes encode proteins homologous to the mammalian tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Inactivation of Smed-P...

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Autors principals: Oviedo, Néstor J., Pearson, Bret J., Levin, Michael, Sánchez Alvarado, Alejandro
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists Limited 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562200/
https://ncbi.nlm.nih.gov/pubmed/19048075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.000117
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