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Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells

The activated amino acid response (AAR) and unfolded protein response (UPR) stress signaling pathways converge at the phosphorylation of translation initiation factor eIF2α. This eIF2α modification suppresses global protein synthesis but enhances translation of selected mRNAs such as that for activa...

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Detalhes bibliográficos
Main Authors: Gjymishka, Altin, Palii, Stela S., Shan, Jixiu, Kilberg, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562058/
https://ncbi.nlm.nih.gov/pubmed/18697751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803781200
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