Despite Increased ATF4 Binding at the C/EBP-ATF Composite Site following Activation of the Unfolded Protein Response, System A Transporter 2 (SNAT2) Transcription Activity Is Repressed in HepG2 Cells

The activated amino acid response (AAR) and unfolded protein response (UPR) stress signaling pathways converge at the phosphorylation of translation initiation factor eIF2α. This eIF2α modification suppresses global protein synthesis but enhances translation of selected mRNAs such as that for activa...

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Bibliographic Details
Main Authors: Gjymishka, Altin, Palii, Stela S., Shan, Jixiu, Kilberg, Michael S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562058/
https://ncbi.nlm.nih.gov/pubmed/18697751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803781200
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