Dominant Alleles Identify SET Domain Residues Required for Histone Methyltransferase of Polycomb Repressive Complex 2

Polycomb gene silencing requires histone methyltransferase activity of Polycomb repressive complex 2 (PRC2), which methylates lysine 27 of histone H3. Information on how PRC2 works is limited by lack of structural data on the catalytic subunit, Enhancer of zeste (E(Z)), and the paucity of E(z) mutan...

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Bibliographic Details
Main Authors: Joshi, Preeti, Carrington, Elizabeth A., Wang, Liangjun, Ketel, Carrie S., Miller, Ellen L., Jones, Richard S., Simon, Jeffrey A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Transcription, Chromatin, and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562053/
https://ncbi.nlm.nih.gov/pubmed/18693240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804442200
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