Reduced genotoxicity of avian sarcoma leukosis virus vectors in rhesus long-term repopulating cells compared to standard murine retrovirus vectors

Insertional mutagenesis continues to be a major concern in hematopoietic stem cell gene therapy. Non-conventional gene transfer vectors with more favorable integration features in comparison to conventional retrovirus and lentivirus vectors are being developed and optimized. Here we reported for the...

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Autores principales: Hu, Jingqiong, Renaud, Gabriel, Golmes, Theotonius, Ferris, Andrea, Hendrie, Paul C., Donahue, Robert E., Hughes, Stephen H., Wolfsberg, Tyra G., Russell, David W., Dunbar, Cynthia E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561952/
https://ncbi.nlm.nih.gov/pubmed/18578011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.135
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