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Initiation of allelic exclusion by stochastic interaction of Tcrb alleles with repressive nuclear compartments
Earlier studies of antigen-receptor loci implicated directed monoallelic association with peri-centromeric heterochromatin in the initiation or maintenance of allelic exclusion. Here we provide evidence for a fundamentally different basis for Tcrb allelic exclusion. Using 3D Immuno-FISH we found tha...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2561338/ https://ncbi.nlm.nih.gov/pubmed/18536719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1624 |
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