Population pharmacokinetic and pharmacodynamic analysis to support treatment optimization of combination chemotherapy with indisulam and carboplatin

AIMS: Indisulam and carboplatin have shown synergistic activity in preclinical studies. In a dose escalation study of the combination, a treatment delay was frequently required in a 3-weekly regimen to allow recovery from myelosuppression from previous cycles. A 4-weekly regimen was better tolerated...

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Hlavní autoři: Zandvliet, Anthe S, Schellens, Jan H M, Dittrich, Christian, Wanders, Jantien, Beijnen, Jos H, Huitema, Alwin D R
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Pharmacokinetic Dynamic Relationships
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561111/
https://ncbi.nlm.nih.gov/pubmed/18637887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03230.x
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