Use of an Oncolytic Virus Secreting GM-CSF as Combined Oncolytic and Immunotherapy for Treatment of Colorectal and Hepatic Adenocarcinomas

Oncolytic cancer therapy using herpes simplex viruses (HSV) that have direct tumoricidal effects and cancer immunotherapy using the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) have each been effective in preclinical testing. NV1034 is a multi-mutated oncolytic HSV carrying the...

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Bibliographic Details
Main Authors: Malhotra, Sandeep, Kim, Teresa, Zager, Jonathan, Bennett, Joseph, Ebright, Michael, D’Angelica, Michael, Fong, Yuman
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559995/
https://ncbi.nlm.nih.gov/pubmed/17383529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2006.10.010
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