Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification

Cartilage extracellular matrix (ECM) contains large amounts of proteoglycans made of a protein core decorated by highly sulfated sugar chains, the glycosaminoglycans (GAGs). GAGs desulfation, a necessary step for their degradation, is exerted by sulfatases that are activated by another enzyme, Sulfa...

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Autori principali: Settembre, Carmine, Arteaga-Solis, Emilio, McKee, Marc D., de Pablo, Raquel, Al Awqati, Qais, Ballabio, Andrea, Karsenty, Gerard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559909/
https://ncbi.nlm.nih.gov/pubmed/18832069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1711308
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