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Functional Deficits in nNOSμ-Deficient Skeletal Muscle: Myopathy in nNOS Knockout Mice

Skeletal muscle nNOSμ (neuronal nitric oxide synthase mu) localizes to the sarcolemma through interaction with the dystrophin-associated glycoprotein (DAG) complex, where it synthesizes nitric oxide (NO). Disruption of the DAG complex occurs in dystrophinopathies and sarcoglycanopathies, two genetic...

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Autors principals: Percival, Justin M., Anderson, Kendra N. E., Gregorevic, Paul, Chamberlain, Jeffrey S., Froehner, Stanley C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559862/
https://ncbi.nlm.nih.gov/pubmed/18852886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003387
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