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Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential

PURPOSE: Safety and efficiency are critical for successful gene therapy. Adeno-associated viral (AAV) vectors are commonly used for gene transfer in both human and animal studies. However, administration of AAV vectors can lead to development of neutralizing antibodies against the vector capsid, thu...

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Main Authors: Li, Qiuhong, Miller, Rehae, Han, Ping-Yang, Pang, Jijing, Dinculescu, Astra, Chiodo, Vince, Hauswirth, William W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Molecular Vision 2008
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2559816/
https://ncbi.nlm.nih.gov/pubmed/18836574
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