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Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease

Maintaining tolerance of T cells to self-antigens is essential to avoid autoimmune disease. How self-reactive T cells are kept functionally inactive is, however, unknown. In this study, we show that early growth response gene 2 (Egr-2), a zinc-finger transcription factor, is expressed in CD44(high)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhu, Bo, Symonds, Alistair L.J., Martin, Joanne E., Kioussis, Dimitris, Wraith, David C., Li, Suling, Wang, Ping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556781/
https://ncbi.nlm.nih.gov/pubmed/18779345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080187
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