Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation

Egr2 and 3 are important for maintaining immune homeostasis. Here we define a fundamental function of Egr2 and 3 operating as a checkpoint that controls the transition between clonal expansion and differentiation of effector T cells. Egr2 and 3 deficiency resulted in defective clonal expansion but h...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Miao, Tizong, Symonds, Alistair L.J., Singh, Randeep, Symonds, Janine D., Ogbe, Ane, Omodho, Becky, Zhu, Bo, Li, Suling, Wang, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460991/
https://ncbi.nlm.nih.gov/pubmed/28487311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160553
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