Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction

INTRODUCTION: Several studies link hematological dysfunction to severity of sepsis. Previously we showed that platelet-derived microparticles from septic patients induce vascular cell apoptosis through the NADPH oxidase-dependent release of superoxide. We sought to further characterize the micropart...

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Detalhes bibliográficos
Main Authors: Gambim, Marcela Helena, de Oliveira do Carmo, Alipio, Marti, Luciana, Veríssimo-Filho, Sidney, Lopes, Lucia Rossetti, Janiszewski, Mariano
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556756/
https://ncbi.nlm.nih.gov/pubmed/17894858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc6133
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