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Simplified Synthetic TMC-95A/B Analogues Retain the Potency of Proteasome Inhibitory Activity

The proteasome regulates diverse intracellular processes, including cell-cycle progression, antigen presentation, and inflammatory response. Selective inhibitors of the proteasome have great therapeutic potential for the treatment of cancer and inflammatory disorders. Natural cyclic peptides TMC-95A...

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Detalhes bibliográficos
Main Authors: Yang, Zhi-Qiang, Kwok, Benjamin H. B., Lin, Songnian, Koldobskiy, Michael A., Crews, Craig M., Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556569/
https://ncbi.nlm.nih.gov/pubmed/12794861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200300560
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