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Computational studies reveal phosphorylation dependent changes in the unstructured R domain of CFTR
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a cAMP dependent chloride channel that is mutated in cystic fibrosis, an inherited disease of high morbidity and mortality. The phosphorylation of its ∼200 amino acid R domain by protein kinase A is obligatory for channel gating under...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2556564/ https://ncbi.nlm.nih.gov/pubmed/18423665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.03.033 |
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