Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle.

Lysosomotropic drugs such as NH4Cl have been useful for studying the role of low pH in early events in virus infection. NH4Cl blocks the production of infectious progeny virus in mammalian reovirus-infected cells. The inhibitory effect of NH4Cl is mediated by an inhibition of intracellular digestion...

Full description

Saved in:
Bibliographic Details
Main Authors: Sturzenbecker, L J, Nibert, M, Furlong, D, Fields, B N
Format: Artigo
Language:Inglês
Published: 1987
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC255643/
https://ncbi.nlm.nih.gov/pubmed/2885424
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items