Intracellular digestion of reovirus particles requires a low pH and is an essential step in the viral infectious cycle.

Lysosomotropic drugs such as NH4Cl have been useful for studying the role of low pH in early events in virus infection. NH4Cl blocks the production of infectious progeny virus in mammalian reovirus-infected cells. The inhibitory effect of NH4Cl is mediated by an inhibition of intracellular digestion...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Sturzenbecker, L J, Nibert, M, Furlong, D, Fields, B N
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1987
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC255643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2885424/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.61.8.2351-2361.1987
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