Amyotrophic Lateral Sclerosis 2-Deficiency Leads to Neuronal Degeneration in Amyotrophic Lateral Sclerosis through Altered AMPA Receptor Trafficking

Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, howev...

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Hoofdauteurs: Lai, Chen, Xie, Chengsong, McCormack, Stefanie G., Chiang, Hsueh-Cheng, Michalak, Marta K., Lin, Xian, Chandran, Jayanth, Shim, Hoon, Shimoji, Mika, Cookson, Mark R., Huganir, Richard L., Rothstein, Jeffrey D., Price, Donald L., Wong, Philip C., Martin, Lee J., Zhu, J. Julius, Cai, Huaibin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Society for Neuroscience 2006
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556290/
https://ncbi.nlm.nih.gov/pubmed/17093100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2084-06.2006
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