Functional Hierarchy of Simultaneously Expressed Adhesion Receptors: Integrin α2β1 but Not CD44 Mediates MV3 Melanoma Cell Migration and Matrix Reorganization within Three-dimensional Hyaluronan-containing Collagen Matrices

Haptokinetic cell migration across surfaces is mediated by adhesion receptors including β1 integrins and CD44 providing adhesion to extracellular matrix (ECM) ligands such as collagen and hyaluronan (HA), respectively. Little is known, however, about how such different receptor systems synergize for...

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Main Authors: Maaser, Kerstin, Wolf, Katarina, Klein, C. Eberhard, Niggemann, Bernd, Zänker, Kurt S., Bröcker, Eva-B., Friedl, Peter
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC25559/
https://ncbi.nlm.nih.gov/pubmed/10512851
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