Glucosamine increases hyaluronic acid production in human osteoarthritic synovium explants

BACKGROUND: Glucosamine (GlcN) used by patients with osteoarthritis was demonstrated to reduce pain, but the working mechanism is still not clear. Viscosupplementation with hyaluronic acid (HA) is also described to reduce pain in osteoarthritis. The synthesis of HA requires GlcN as one of its main b...

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Bibliographic Details
Main Authors: Uitterlinden, EJ, Koevoet, JLM, Verkoelen, CF, Bierma-Zeinstra, SMA, Jahr, H, Weinans, H, Verhaar, JAN, van Osch, GJVM
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553787/
https://ncbi.nlm.nih.gov/pubmed/18786270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-9-120
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