DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts

Replication origins in Xenopus egg extracts are located at apparently random sequences but are activated in clusters that fire at different times during S phase under the control of ATR/ATM kinases. We investigated whether chromosomal domains and single sequences replicate at distinct times during S...

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Bibliografske podrobnosti
Main Authors: Labit, Hélène, Perewoska, Irène, Germe, Thomas, Hyrien, Olivier, Marheineke, Kathrin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Genome Integrity, Repair and Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553594/
https://ncbi.nlm.nih.gov/pubmed/18765475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn533
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