Activated transcription via mammalian amino acid response elements does not require enhanced recruitment of the Mediator complex

It is unclear whether Mediator complex in yeast is necessary for all RNA polymerase II (Pol II) transcription or if it is limited to genes activated by environmental stress. In mammals, amino acid limitation induces SNAT2 transcription through ATF4 binding at an amino acid response element. ATF4 is...

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Bibliographic Details
Main Authors: Thiaville, Michelle M., Dudenhausen, Elizabeth E., Awad, Keytam S., Gjymishka, Altin, Zhong, Can, Kilberg, Michael S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553592/
https://ncbi.nlm.nih.gov/pubmed/18757893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn538
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